7-(Ethoxycarbonyl)-6,8-dimethyl-2-phenyl-1(2H)-phthalazinone derivatives: synthesis and inhibitory effects on platelet aggregation.

doi:10.1021/JM00376A013

Paper

7-(Ethoxycarbonyl)-6,8-dimethyl-2-phenyl-1(2H)-phthalazinone derivatives: synthesis and inhibitory effects on platelet aggregation.

Published Oct 1, 1984 · A. Sugimoto, H. Tanaka, Y. Eguchi

Journal of medicinal chemistry

Q1 SJR score

24

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0

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Abstract

7-(Ethoxycarbonyl)-6,8-dimethyl-2-phenyl-1(2H)-phthalazinone derivatives and several analogues were synthesized and their inhibitory effects on platelet aggregation were evaluated. Structure-activity relationships are discussed. All synthesized compounds showed no appreciable effect on platelet aggregation induced by adenosine diphosphate, but most of them inhibited effectively the arachidonic acid induced platelet aggregation. The parent compound, 2-phenyl derivatives, and ortho-substituted 2-phenyl derivatives show the most potent inhibition of all compounds.

In Vitro Study

Study Snapshot

7-(Ethoxycarbonyl)-6,8-dimethyl-2-phenyl-1(2H)-phthalazinone derivatives effectively inhibit arachidonic acid-induced platelet aggregation, with the most potent inhibition observed in the parent compound and 2-phenyl derivatives.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

7-(Ethoxycarbonyl)-6,8-dimethyl-2-phenyl-1(2H)-phthalazinone derivatives: synthesis and inhibitory effects on platelet aggregation.

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References

Citations

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Phthalazin-1(2H)-one as a remarkable scaffold in drug discovery.

Phthalazinone derivatives show diverse pharmacological properties, making them a promising scaffold for designing and developing new drugs with diverse therapeutic effects.

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Zinc-mediated ring contraction of 1,3-diphenylbenzo[1,2,4]triazinyl radicals to 1,2-diphenylbenzimidazoles in high yield provides a versatile method for preparing various benzimidazoles.

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