7-Hydroxytropolone: an inhibitor of aminoglycoside-2"-O-adenylyltransferase

doi:10.1128/AAC.22.5.824

Paper

7-Hydroxytropolone: an inhibitor of aminoglycoside-2"-O-adenylyltransferase

Published Nov 1, 1982 · N. E. Allen, W. Alborn, J. N. Hobbs

Antimicrobial Agents and Chemotherapy

Q1 SJR score

62

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2

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Abstract

Aminoglycoside-2"-O-adenylyltransferase was inhibited by 7-hydroxytropolone. Inhibition was competitive with respect to the cosubstrate ATP and appeared to require the unique vicinal arrangement of oxygens found in 7-hydroxytropolone. Combinations of 7-hydroxytropolone plus the appropriate aminoglycoside substrates were active against resistant bacteria possessing the adenylyltransferase. No potentiation was observed against other aminoglycoside-resistant or -susceptible strains. The fact that the inhibition of an aminoglycoside-modifying enzyme overcomes the poor uptake of aminoglycosides in resistant strains points to the singular importance of the inactivating enzyme as a determinant of resistance.

Study Snapshot

7-hydroxytropolone effectively inhibits aminoglycoside-2"-O-adenylyltransferase, enabling the uptake of aminoglycosides in resistant bacteria, emphasizing the importance of this enzyme in resistance determinants.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

7-Hydroxytropolone: an inhibitor of aminoglycoside-2"-O-adenylyltransferase

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Citations

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Antibiofilm agents targeting diverse stages of biofilm formation show promise in overcoming antibiotic resistance and improving disease management.

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Pseudomonas donghuensis P482's antibacterial activity and gene expression are influenced by the carbon source, with glycerol negatively impacting 7-hydroxytropolone synthesis.