7-Nitro indazole, a neuron-specific nitric oxide synthase inhibitor, produces amnesia in the chick.

doi:10.1101/LM.1.4.213

Paper

7-Nitro indazole, a neuron-specific nitric oxide synthase inhibitor, produces amnesia in the chick.

Published Nov 1, 1994 · C. Hölscher

Learning & memory

Q2 SJR score

24

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0

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Abstract

7-Nitro indazole (7-NI), which is selective for the neuronal isoform of nitric oxide synthase (NOS), was tested in a passive avoidance task in the chick. Injection of 50 mg/kg i.p. pretraining had amnesic effects for the task when tested 30 min, 2 or 24 hr after training. Injections post-training had no effect. Because 7-NI does not inhibit the endothelial isoform of NOS, it does not affect blood vessel relaxation, as nonspecific inhibitors do. This effect on blood vessels could explain the amnestic effects produced by nonspecific NOS inhibitors. The results support the theory that NO is a neuronal transmitter that is important in processes of synaptic plasticity and learning.

Non-RCT

Animal Study

Study Snapshot

7-Nitro indazole, a neuron-specific nitric oxide synthase inhibitor, produces amnesia in chicks, supporting the theory that nitric oxide plays a role in synaptic plasticity and learning.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

7-Nitro indazole, a neuron-specific nitric oxide synthase inhibitor, produces amnesia in the chick.

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References

Inhibition of Nitric Oxide Synthesis: Effects on Cerebral Blood Flow and Glucose Utilisation in the Rat

Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats.

Inhibiting synthesis of the putative retrograde messenger nitric oxide results in amnesia in a passive avoidance task in the chick

Localization of NADPH‐diaphorase in the brain of the chicken

7‐Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti‐nociceptive activity in the mouse without increasing blood pressure

Citations

Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives

The synthesized compounds show promising antimicrobial, analgesic, and anti-inflammatory properties.

Catalysis by Amberlyst A-21: A Greener Approach to 4,5,6,7-Tetrahydro-1H-indazol-3(2H)-ones via Construction of Cyclohexanones

Amberlyst A-21 is an inexpensive, reusable catalyst for synthesizing 4,5,6,7-tetrahydro-1H-indazol-3(2H)-ones in a greener, environmentally friendly manner.

Effects of nitric oxide synthase inhibitors 1‐(2‐trifluoromethylphenyl) – imidazole (TRIM) and 7‐nitroindazole (7‐NI) on learning and memory in mice

TRIM has no clear effect on cognitive impairment compared to 7-NI, and both neuronal and endothelial nitric oxide synthase inhibitors contribute to memory deterioration.

Nitric Oxide Synthase Inhibitors as Antidepressants

Nitric oxide synthase inhibitors show potential as antidepressants and anxiolytics in anxiety and depression, potentially improving mood and quality of life.

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

GLP-1 receptors play a crucial role in synaptic plasticity and memory formation, potentially explaining their neuroprotective properties in Alzheimer's disease animal models.