7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization.

doi:10.1016/j.bmcl.2009.02.071

Paper

7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization.

Published Apr 1, 2009 · P. Fish, A. Brown, Edelweiss Evrard

Bioorganic & medicinal chemistry letters

Q2 SJR score

32

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0

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Abstract

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Study Snapshot

7-sulfonamido-3-benzazepines are potent 5-HT2C receptor agonists with minimal activation of 5-HT2A and 5-HT2B receptors and excellent in vitro ADME properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization.

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