9-Methylfluorene was tested as an indicator in the titration of commonly used organometallic reagents. This indicator is readily prepared in three steps from fluorenone. In THF solution the deprotonated indicator is red and exhibits a sharp endpoint. The highly basic reagents sec-butyllithium and tert-butyllithium can be titrated in ether solution, where the color of the deprotonated indicator is yellow.

9-methylfluorene is a useful indicator for titration of common organometallic reagents, with a red color in THF solution and yellow color in ether solution.

Paper

Use of 9-methylfluorene as an indicator in the titration of common group IA and group IIA organometallic reagents.

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