Paper

9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.

Published Nov 1, 2017 · G. Makhaeva, S. Lushchekina, N. Boltneva

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

9-Substituted acridine derivatives show potential as effective and selective cholinesterase inhibitors with high antioxidant activity, offering potential for multifunctional drugs in neurodegenerative disease therapy.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.

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