Paper
A Practical Access to Optically Pure (S)-1-Octyn-3-ol
Published Mar 1, 1991 · S. Hashimoto*, Satoshi Kase, A. Suzuki
Synthetic Communications
15
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Abstract
Abstract A highly efficient resolution of (±)-1-octyn-3-ol through recrytallization of the diastereomeric esters has been achieved by using N-(p-toluenesulfonyl)-(S)-phenylalanyl chloride as resolving reagent. The method provides a facile and economical entry to (S)-1-octyn-3-ol, a valuable building block for the synthesis of arachidonic acid metabolites.
This study presents a facile and economical method for obtaining (S)-1-octyn-3-ol, a valuable building block for the synthesis of arachidonic acid metabolites, using N-(p-toluenesulfonyl)-(S)-phen
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