Paper

Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).

Published Sep 1, 2010 · P. Galatsis, B. Caprathe, J. Gilmore

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

Succinic acid amides are effective P2-P3 scaffold replacements for peptidic ICE inhibitors, with 17f identified as a potential clinical candidate.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).

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