N-sulfonic acid poly(4-vinylpyridinium) chloride is easily prepared by the reaction of poly(4-vinylpyridine) with neat chlorosulfonic acid. This reagent can be used as an efficient catalyst for the N-Boc protection of amines at room temperature and neat conditions. This new method consistently has the advantages of excellent yields and short reaction times. Further, the catalyst can be reused and recovered for several times.

N-sulfonic acid poly(4-vinylpyridinium) chloride is an efficient and reusable catalyst for N-Boc protection of amines, offering excellent yields and short reaction times.

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N-sulfonic acid poly(4-vinylpyridinium) chloride: an efficient and reusable solid acid catalyst in N-Boc protection of amines

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