Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with 2-alkylquinoline-3-carbaldehydes as well as the corresponding 4-alkyl isomers and pyridine analogues. These processes involve dual C–H bond functionalization. Acetic acid is used as a cosolvent and acts as the sole promoter of these transformations.

Acetic acid promotes redox-neutral annulations with 2-alkylquinoline-3-carbaldehydes, leading to dual C-H bond functionalization in amides and pyridine analogues.

Paper

Acetic Acid Promoted Redox Annulations with Dual C–H Functionalization

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