Paper

5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII.

Published Aug 1, 2015 · Ilija N. Cvijetić, Muhammet Tanc, I. Juranić

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Selective inhibition of human carbonic anhydrase IX and XII by 5-aryl-1H-pyrazole-3-carboxylic acids could lead to the development of isoform-specific non-sulfonamide CA inhibitors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII.

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