Paper

6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain.

Published Jun 2, 2003 · Yun-fei Zhu, K. Wilcoxen, T. Gross

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

Optimizing the 1-position benzoyl side chain of 1-benzoyl isoquinolines can lead to potent inhibitors of insulin-like growth factor binding, with less labile catechol functionality.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain.

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