Hypotensive Action of 3α-Dihydrocadambine, An Indole Alkaloid Glycoside of Uncaria Hooks

doi:10.1055/S-2007-969538

Paper

Hypotensive Action of 3α-Dihydrocadambine, An Indole Alkaloid Glycoside of Uncaria Hooks

Published Oct 1, 1985 · K. Aisaka, Y. Hattori, T. Kihara

Planta Medica

Q2 SJR score

21

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0

Influential Citations

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Abstract

: 3alpha-Dihydrocadambine exhibited dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats. Its activity was much stronger and longer-lasting than that of rhynchophylline. In anesthetized dogs, it caused dilation of the vertebral, femoral and common carotid arteries, and had almost no effect on the coronary artery, whereas it had almost no significant activity in isolated canine arterial strip preparations.

Non-RCT

Animal Study

Study Snapshot

3alpha-Dihydrocadambine, an Indole alkaloid glycoside from Uncaria Hooks, exhibits strong and longer-lasting hypotensive effects in rats and dogs, with no significant activity in isolated canine arterial strip preparations.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Hypotensive Action of 3α-Dihydrocadambine, An Indole Alkaloid Glycoside of Uncaria Hooks

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References

Citations

Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry.

Uncaria spp. alkaloids show potential in treating various diseases, including hypertension, Alzheimer's disease, drug addiction, and inflammation, with potential for new drug discovery and development.

Total Syntheses of (-)-Strictosidine and Related Indole Alkaloid Glycosides.

This study developed a two-step protocol for the synthesis of (-)-strictosidine and related indole alkaloid glycosides, enabling the first enantioselective total synthesis of (-)-strictosidine in 10 steps.

A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer’s Disease

Uncaria alkaloids show potential in treating hypertension and preventing Alzheimer's disease, with their mechanisms being influenced by complex biological interactions.

Evaluation of the effects of Uncaria rhynchophylla alkaloid extract on LPS-induced preeclampsia symptoms and inflammation in a pregnant rat model

Uncaria rhynchophylla alkaloid extract (URE) improves preeclampsia symptoms and mitigates inflammation in a rat model, suggesting its potential as an alternative therapy for preeclampsia.

Simultaneous determination of eight bioactive compounds by LC-MS/MS and its application to the pharmacokinetics, liver first-pass effect, liver and brain distribution of orally administrated Gouteng-Baitouweng (GB) in rats.

Orally administered Gouteng-Baitouweng (GB) shows pharmacokinetics, liver first-pass effect, and liver and brain distribution, providing a solid foundation for interpreting its efficacy and safety.