THE ACTION OF CERTAIN CYCLOHEXAMINES ON HIPPOCAMPAL SYSTEM DURING APPROACH PERFORMANCE IN THE CAT

doi:10.1016/s0022-3565(25)25918-3

Paper

THE ACTION OF CERTAIN CYCLOHEXAMINES ON HIPPOCAMPAL SYSTEM DURING APPROACH PERFORMANCE IN THE CAT

Published Dec 1, 1960 · W. R. Adey, C. Dunlop

The Journal of Pharmacology and Experimental Therapeutics

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

Cyclohexamine derivatives can suppress learned approach behavior in cats, affecting their goal-directed motor activity and causing seizure spiking in the hippocampal system.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

THE ACTION OF CERTAIN CYCLOHEXAMINES ON HIPPOCAMPAL SYSTEM DURING APPROACH PERFORMANCE IN THE CAT

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References

Citations

N-methyl-D-aspartate receptors in associative eyeblink conditioning: both MK-801 and phencyclidine produce task- and dose-dependent impairments.

N-methyl-D-aspartate receptor blockade impairs rabbit eyeblink conditioning, with dose and task-dependent impairments, but does not affect retention or timing of previously learned responses.

Suppression of serotonin-dependent cerebral activation: a possible mechanism of action of some psychotomimetic drugs

Psychotomimetic drugs like phencyclidine and opioids may partially work by suppressing serotonin-dependent activation of the cerebral cortex.

Interactions of phencyclidine with hippocampal circuitry: Evidence for neuronal heterogeneity

Metaphit effectively reduces the effects of PCP on hippocampal neurons, suggesting two distinct mechanisms of action and potential cell type specificity.

Phencyclidine (PCP): effects of acute and chronic administration on EEG activities in the rhesus monkey.

Phencyclidine (PCP) administration in monkeys produces a biphasic pattern of inhibitory and excitatory effects, with chronic administration leading to tolerance to the inhibitory effect and an augmentation of the excitatory effect.

Phencyclidine (PCP): Effects on limbic afterdischarges in the rhesus monkey

Phencyclidine (PCP) significantly reduces the ability of electrical stimulation to elicit afterdischarges in the hippocampus, amygdala, and midbrain reticular formation in rhesus monkeys.