Summary 1.Glyoxal bis(thiosemicarbazone) and a number of its derivatives were inhibitory to Sarcoma 180 in Swiss mice. 2.The bis(N 4 methylthiosemicarbazones) of hydroxymethylglyoxal, methylglyoxal, and ethoxymethylglyoxal were the most active members of the series reported. 3.Early or, especially, prophylactic treatment resulted in a marked and persistent incidence of “non-takes” of the tumor transplants. 4.A possible mechanism of action based on heavy metal chelation is discussed.

Glyoxal bis(thiosemicarbazone) and its derivatives show inhibitory effects on Sarcoma 180 in mice, potentially due to heavy metal chelation.

Paper

Carcinostatic action of polycarbonyl compounds and their derivatives. IV. Glyoxal bis (thiosemicarbazone) and derivatives.

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