Paper

Neuroprotective action of raloxifene against hypoxia-induced damage in mouse hippocampal cells depends on ERα but not ERβ or GPR30 signalling

Published Feb 1, 2015 · J. Rzemieniec, E. Litwa, A. Wnuk

The Journal of Steroid Biochemistry and Molecular Biology

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Abstract

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In Vitro Study

Study Snapshot

Raloxifene shows strong neuroprotective and anti-apoptotic effects in mouse hippocampal cells exposed to hypoxia, primarily involving ER signaling, but not ER or GPR30.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Neuroprotective action of raloxifene against hypoxia-induced damage in mouse hippocampal cells depends on ERα but not ERβ or GPR30 signalling

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