Paper
The action of triethylcholine on the biological synthesis of acetylcholine.
Published Aug 1, 1965 · DOI · G. Bull, B. Hemsworth
British journal of pharmacology and chemotherapy
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Abstract
Triethylcholine causes a slowly developing failure of neuromuscular transmission in rapidly stimulated nerve-muscle preparations. At the time of maximal depression of the muscle twitches, the response to a close-arterial injection of acetylcholine is normal, suggesting that the site of the transmission failure is prejunctional (Bowman & Rand, 1961; Bowman, Hemsworth & Rand, 1962). In the isolated phrenic nerve-diaphragm preparation of the rat, concentrations of triethylcholine which interrupt neuromuscular transmission also cause a decrease in acetylcholine output from the stimulated nerve. The addition of choline restores both the contractions and the acetylcholine output towards normal (Bowman & Hemsworth, 1965). The action of triethylcholine therefore appears to resemble that of the hemicholiniums which are believed to interrupt cholinergic transmission by interfering with the synthesis of acetylcholine at the nerve endings (Schueler, 1960). The experiments described in this paper were designed to provide direct evidence of any action of triethylcholine on acetylcholine synthesis in nervous tissue. Some of the results have been briefly reported elsewhere (Bull & Hemsworth, 1963).
Triethylcholine disrupts neuromuscular transmission by interfering with acetylcholine synthesis in nerve tissue, resembles the action of hemicholiniums.
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