A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides.

This novel methodology efficiently synthesizes non-symmetric 1,3,4-oxadiazoles using polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides.

Paper

Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles

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