Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells.

doi:10.1016/J.BMC.2007.05.030

Paper

Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells.

Published Aug 1, 2007 · D. Kaufmann, M. Pojarová, S. Vogel

Bioorganic & medicinal chemistry

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69

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Abstract

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Study Snapshot

2-phenylindole-3-carbaldehydes with 4-methoxy groups in the 2-phenyl ring strongly inhibit breast cancer cell growth, likely due to cell cycle arrest in G(2)/M phase due to tubulin polymerization inhibition.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells.

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References

Indole, a core nucleus for potent inhibitors of tubulin polymerization

Indole-based anti-tubulin agents show potential in anti-cancer therapy by modulating microtubule assembly and inhibiting tubulin polymerization.

Structure–Activity Relationship Studies of 3‐Aroylindoles as Potent Antimitotic Agents

3'-aroylindoles show potential as potent antimitotic agents by retaining cytotoxic and antitubulin activities while modifying their structure to enhance their anticancer properties.

Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.

Combretastatin A-4 analogs derived from SU5416 show promising cytotoxic effects against PC-3 and MDA-MB-231 cancer cell lines and inhibition of tubulin polymerization compared to compound 1.

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors.

2-(3',4',5'-trimethoxybenzoyl)-3-amino-5-aryl thiophenes show potential as a new class of tubulin inhibitors, with various substitutions at the 5-phenyl group affecting antiproliferative activity and cell

Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents.

Indolic analogues of CSA-4 show potential as antivascular agents, with potential cytotoxic activities on B16 melanoma cells and inhibitory effects on tubulin polymerization.

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