Contraceptive activity of 4-(4-hydroxy-3-methyl-hex-5-enyl)-chroman-2,7-diol via inhibiting ovulation in Gonadotropin-primed immature rat model

doi:10.1016/J.BIOMAG.2013.12.001

Paper

Contraceptive activity of 4-(4-hydroxy-3-methyl-hex-5-enyl)-chroman-2,7-diol via inhibiting ovulation in Gonadotropin-primed immature rat model

Published 2014 · Ashoke Kumar, S. Gullaiya, V. Dubey

Biomedicine & Aging Pathology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

The chroman derivative from Ensete superbum seeds has potential contraceptive activity through its anti-estrogenic activity, inhibiting ovulation and disrupting ovarian cytokinine signaling.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Contraceptive activity of 4-(4-hydroxy-3-methyl-hex-5-enyl)-chroman-2,7-diol via inhibiting ovulation in Gonadotropin-primed immature rat model

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References

Antifertility activity of methanolic bark extract of Aegle marmelos (l.) in male wistar rats

Aegle marmelos bark methanolic extract shows potential as a male contraceptive due to its ability to produce complete inhibition of pregnancy, rapid restoration of fertility after withdrawal, and its lipid correcting ability.

Control of ovulation in mice by progesterone receptor-regulated gene networks.

Progesterone receptor-regulated gene networks play a crucial role in regulating ovulation in mice, potentially aiding in the development of improved contraceptives and treatments for anovulatory infertility.

Antiovulatory effect of a single injection of pure antiestrogen ZK 191703 at early stage of rat estrus cycle

A single injection of ZK 191703 or tamoxifen at an early stage of the rat estrus cycle inhibits ovulation and suppresses preovulatory progesterone surge, effectively delaying follicular development.

Investigation of ethnomedicinal claims of some plants used by tribals of Satpuda Hills in India.

Tribals in Satpuda Hills, India, use 52 species of medicinal plants to treat various diseases, revealing 14 new ethnomedicinal uses not previously reported in literature.

Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain.

Circulating interleukin-6 induces fever in the brain through a STAT3-dependent pathway, suggesting it plays a crucial role in fever initiation and maintenance.

Citations

Wild banana [Ensete superbum (Roxb.) Cheesman.]: Ethnomedicinal, phytochemical and pharmacological overview.

E. superbum, commonly known as "Wild Banana," is a safe and effective source of medicinal and nutritional herbal remedies for human and animal consumption.

Antifertility Activity of Ethanol Leaf Extract of Moringa oleifera Lam in Female Wistar Rats

Moringa oleifera ethanol extract at 250 and 500 mg/kg doses shows antifertility activity by inhibiting implantation in female rats, requiring further evaluation for potential contraceptive action.