Anticonvulsant and antinociceptive activity of new amides derived from 3-phenyl-2,5-dioxo-pyrrolidine-1-yl-acetic acid in mice.

doi:10.1016/j.ejphar.2016.04.033

Paper

Anticonvulsant and antinociceptive activity of new amides derived from 3-phenyl-2,5-dioxo-pyrrolidine-1-yl-acetic acid in mice.

Published Jun 15, 2016 · A. Rapacz, J. Obniska, Beata Wiklik-Poudel

European journal of pharmacology

Q1 SJR score

20

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Three new amides derived from 3-phenyl-2,5-dioxo-pyrrolidine-1-yl-acetic acid show broad anticonvulsant activity and significant analgesic properties in mice models.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Anticonvulsant and antinociceptive activity of new amides derived from 3-phenyl-2,5-dioxo-pyrrolidine-1-yl-acetic acid in mice.

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