Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro.

doi:10.1016/0378-8741(95)01331-8

Paper

DOI: 10.1016/0378-8741(95)01331-8

Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro.

Published 1996 · John M. Grange, Noel Snell

Journal of ethnopharmacology

Q1 SJR score

142

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

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Study Snapshot

Bromhexine and ambroxol show potential as adjunctive therapies in tuberculosis therapy due to their pH-dependent growth-inhibitory effect on Mycobacterium tuberculosis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Effect of ambroxol on human phagocytic cell function.

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The absorption, excretion and metabolic pattern of bromhexine in man after oral and i.v. administration.

Bromhexine's absorption, excretion, and metabolic patterns show slight variations between oral and intravenous administration, due to different distribution patterns in the liver and tissues.

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Citations

DOI: 10.1007/s42535-025-01161-w

Biosynthesis, therapeutic characteristics, origin and strategies to improve the yield of vasicine in plants

Vasicine, found in medicinal plants, has potential health benefits, including antiviral, antimicrobial, and antioxidant properties, and its production can be improved through CRISPR Cas technologies.

2025·0citations·Deepthi Padmanabhan et al.·Vegetos

Vegetos

DOI: 10.52711/0974-360x.2024.00538

Indian Medicinal Plants: A Source of Anti-tuberculosis Drug

Indian medicinal plants exhibit anti-TB activities, offering potential for novel TB treatments and a holistic understanding of the disease.

2024·0citations·Shivendra Singh Dewhare·Research Journal of Pharmacy and Technology

Research Journal of Pharmacy and Technology

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A Review on Concept of Malabar Nut

Malabar nut is a valuable medicinal plant used to treat various illnesses, particularly respiratory conditions, with its primary chemical component, vasicine, having therapeutic uses in various ayurvedic formulas.

2024·0citations·Shruti Satish Garad et al.·International Journal For Multidisciplinary Research

International Journal For Multidisciplinary Research

DOI: 10.1016/j.heliyon.2024.e25727

Exploring the pharmacological and chemical aspects of pyrrolo-quinazoline derivatives in Adhatoda vasica

Adhatoda vasica, commonly known as Adosa, possesses anti-inflammatory, antimicrobial, and anti-tuberculosis properties, with potential for new drug development based on its pyrrolo-quinazoline derivatives.

2024·8citations·Poonam Khandelwal et al.·Heliyon

Heliyon

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A liquid culture system for plantlet conversion and slow growth storage of encapsulated shoot tips of Justicia adhatoda L.

Liquid medium effectively propagates and stores synthetic seeds of Justicia adhatoda L., a medicinal plant used in ayurvedic drugs, with over 50% conversion to plantlets after 60 days of slow-growth storage.

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Exploring and exploiting the host cell autophagy during Mycobacterium tuberculosis infection

Autophagy-inducing chemotherapeutics could shorten treatment duration and enhance cure rates for multidrug-resistant and extreme drug-resistant tuberculosis.

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Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride Orally Disintegrating Tablets (ODTs)

The developed formula for bromhexine hydrochloride orally disintegrating tablets (ODTs) meets EMA requirements and is suitable for registration without bioequivalence testing.

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Pharmaceutical Research

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NEW METHODS FOR DETERMINATION OF AMBROXOL HYDROCHLORIDE IN PURE FORM AND FARMACEUTICAL FORMULATIONS BASED ON SPECTROPHOTOMETRY

The proposed methods are simple, rapid, and accurate for determining Ambroxol Hydrochloride (AMB.HCl) in pure and pharmaceutical forms using spectrophotometry.

2023·0citations·Mohamed Ahmed Saleh Al-Lahji et al.·Electronic Journal of University of Aden for Basic and Applied Sciences

Electronic Journal of University of Aden for Basic and Applied Sciences

DOI: 10.30574/gscbps.2023.23.3.0197

Pharmaceutical study of Vasa (Adhatoda vasica Linn.) With special reference to its different dosage forms

Vasa (Adhatoda vasica Linn.) is a significant Ayurvedic plant used in various dosage forms as a primary medication and major component in various formulations, with various therapeutic benefits based on vaya, kala, prakriti, and kriti.

2023·0citations·Aditi R. Shinde et al.·GSC Biological and Pharmaceutical Sciences

GSC Biological and Pharmaceutical Sciences