Paper
Activity of the Investigational Fluoroquinolone Finafloxacin against Ciprofloxacin-Sensitive and -Resistant Acinetobacter baumannii Isolates
Published Jan 25, 2010 · P. Higgins, W. Stubbings, H. Wisplinghoff
Antimicrobial Agents and Chemotherapy
58
Citations
1
Influential Citations
Abstract
ABSTRACT This study compared the activity of finafloxacin, a novel fluoroquinolone which shows enhanced activity under acidic pH, and that of ciprofloxacin against Acinetobacter baumannii under standard conditions (pH 7.2) and at a pH of 5.8. Overall, finafloxacin demonstrated superior activity to ciprofloxacin under acidic conditions. Furthermore, finafloxacin showed comparable activity to ciprofloxacin at pH 7.2. Hence, finafloxacin could be a promising new antimicrobial agent for the treatment of A. baumannii infections at acidic body compartments.
In Vitro Study
Rigorous JournalFinafloxacin shows superior activity against Acinetobacter baumannii under acidic conditions, making it a promising new antimicrobial agent for treating infections in acidic body compartments.
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