Paper

Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides.

Published Sep 1, 2004 · J. Epperson, M. Bruce, J. Catt

Bioorganic & medicinal chemistry

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Abstract

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Non-RCTAnimal Study

Study Snapshot

N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide (2b) shows full agonism at human melatonin receptors, demonstrating chronobiotic properties in rats, but is less effective than melatonin in constricting human coronar

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides.

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