Antimycobacterial activity of novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids generated by chemoselective 1,3-dipolar cycloadditions of nitrile oxides.

doi:10.1016/j.bmc.2011.04.033

Paper

Antimycobacterial activity of novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids generated by chemoselective 1,3-dipolar cycloadditions of nitrile oxides.

Published Jun 1, 2011 · R. Ranjith Kumar, S. Perumal, J. Menéndez

Bioorganic & medicinal chemistry

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54

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Abstract

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In Vitro Study

Study Snapshot

Novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids show enhanced antimycobacterial activity, with 3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl] being 1.2, 15.2, and 24.6 times more

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Antimycobacterial activity of novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids generated by chemoselective 1,3-dipolar cycloadditions of nitrile oxides.

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