Recent Advances of 1,3,5-Triazinanes in Aminomethylation and Cycloaddition Reactions

doi:10.1055/s-0040-1707160

Paper

Recent Advances of 1,3,5-Triazinanes in Aminomethylation and Cycloaddition Reactions

Published Jul 6, 2020 · Jia‐Rong Chen, Dong-Dong Liang, W. Xiao

Synthesis

Q2 SJR score

32

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0

Influential Citations

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Abstract

Abstract 1,3,5-Trisubstituted 1,3,5-triazinanes (hexahydro-1,3,5-triazines), as stable and readily available surrogates for formaldimines, have found extensive applications for the construction of various nitrogen-containing compounds. The formaldimines, formed in situ from this reagent class, can participate in various aminomethylation and cycloaddition reactions. This short review presents recent advances in this field with emphasis on the conceptual ideas behind the developed methodologies and the reaction mechanisms. 1 Introduction 2 Aminomethylations with 1,3,5-Triazinanes 3 Cycloadditions with 1,3,5-Triazinanes 3.1 Use of 1,3,5-Triazinanes as Two-Atom Synthons 3.2 Use of 1,3,5-Triazinanes as Three-Atom Synthons 3.3 Use of 1,3,5-Triazinanes as Four-Atom Synthons 3.4 Use of 1,3,5-Triazinanes as Six-Atom Synthons 4 Conclusions

Study Snapshot

1,3,5-triazinanes are effective surrogates for formaldimines in various nitrogen-containing compounds, enabling various aminomethylation and cycloaddition reactions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Recent Advances of 1,3,5-Triazinanes in Aminomethylation and Cycloaddition Reactions

References

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