Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women

doi:10.1289/EHP2199

Paper

Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women

Published Feb 1, 2018 · L. Hooper, M. Young, Joshua P. Keller

Environmental Health Perspectives

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53

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3

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Abstract

Background: Limited evidence links air pollution exposure to chronic cough and sputum production. Few reports have investigated the association between long-term exposure to air pollution and classically defined chronic bronchitis. Objectives: Our objective was to estimate the association between long-term exposure to particulate matter (diameter <10 μm, PM10; <2.5μm, PM2.5), nitrogen dioxide (NO2), and both incident and prevalent chronic bronchitis. Methods: We estimated annual average PM2.5, PM10, and NO2 concentrations using a national land-use regression model with spatial smoothing at home addresses of participants in a prospective nationwide U.S. cohort study of sisters of women with breast cancer. Incident chronic bronchitis and prevalent chronic bronchitis, cough and phlegm, were assessed by questionnaires. Results: Among 47,357 individuals with complete data, 1,383 had prevalent chronic bronchitis at baseline, and 647 incident cases occurred over 5.7-y average follow-up. No associations with incident chronic bronchitis were observed. Prevalent chronic bronchitis was associated with PM10 [adjusted odds ratio (aOR) per interquartile range (IQR) difference (5.8 μg/m3)=1.07; 95% confidence interval (CI): 1.01, 1.13]. In never-smokers, PM2.5 was associated with prevalent chronic bronchitis (aOR=1.18 per IQR difference; 95% CI: 1.04, 1.34), and NO2 was associated with prevalent chronic bronchitis (aOR=1.10; 95% CI=1.01, 1.20), cough (aOR=1.10; 95% CI: 1.05, 1.16), and phlegm (aOR=1.07; 95% CI: 1.01, 1.14); interaction p-values (nonsmokers vs. smokers) <0.05. Conclusions: PM10 exposure was related to chronic bronchitis prevalence. Among never-smokers, PM2.5 and NO2 exposure was associated with chronic bronchitis and component symptoms. Results may have policy ramifications for PM10 regulation by providing evidence for respiratory health effects related to long-term PM10 exposure. https://doi.org/10.1289/EHP2199

Observational Study

Very Rigorous Journal

Study Snapshot

Long-term exposure to PM10, PM2.5, and NO2 air pollution is associated with increased prevalence of chronic bronchitis in never-smokers.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women

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References

Historical Prediction Modeling Approach for Estimating Long-Term Concentrations of PM2.5 in Cohort Studies before the 1999 Implementation of Widespread Monitoring

Our prediction modeling approach accurately estimates long-term PM2.5 exposure health effects in cohort studies before widespread monitoring began in 1999.

Satellite-Based NO2 and Model Validation in a National Prediction Model Based on Universal Kriging and Land-Use Regression.

Satellite data and kriging models together improve NO2 land-use regression models, with satellite data improving predictions for areas far from monitoring locations.

Activation of Proinflammatory Responses in Cells of the Airway Mucosa by Particulate Matter: Oxidant- and Non-Oxidant-Mediated Triggering Mechanisms

Particulate matter exposure activates proinflammatory responses in airway cells through various oxidant and non-oxidant triggering mechanisms, potentially contributing to various diseases.

Disease of the small airways in chronic bronchitis.

Peripheral mucus plugging is a significant feature of chronic bronchitis and is exaggerated in patients with emphysema, contributing to airway obstruction in these patients.

A Unified Spatiotemporal Modeling Approach for Predicting Concentrations of Multiple Air Pollutants in the Multi-Ethnic Study of Atherosclerosis and Air Pollution

This novel spatiotemporal modeling approach accurately predicts fine-scale air pollution concentrations in multiple regions, aiding in long-term health effects research.

Citations

Seasonal outdoor PM10 changes based on the spatial local climate zone distribution

Seasonal changes significantly affect PM10 levels in Tehran, with higher levels in autumn and winter due to low average precipitation, and more changes in urban areas than in non-urban areas.

The Impact of Occupational Exposures on Chronic Rhinosinusitis: A Scoping Review.

Occupational exposures are generally associated with chronic rhinosinusitis diagnosis, but more rigorous research methods and standardized criteria are needed for more specific conclusions.

Prevalence and burden of chronic cough in France

Chronic cough is prevalent in France, negatively affects health-related quality of life, and is associated with increased healthcare resource use.

Exposure to ambient air pollution and chronic bronchitis: Findings from over 6.6 million adults in northwestern China.

Long-term exposure to ambient air pollutants may increase the odds of chronic bronchitis, especially among younger people and those with unhealthy lifestyles.

Clinical features and 1-year outcomes of chronic bronchitis in participants with normal spirometry: results from the ECOPD study in China

Non-obstructive chronic bronchitis (NOCB) is associated with increased risk of acute respiratory events in both never-smokers and ever-smokers, supporting its inclusion in pre-COPD criteria.