Ambient-Temperature Synthesis of (E)-N-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-yl)methanimine

doi:10.3390/M1250

Paper

Ambient-Temperature Synthesis of (E)-N-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-yl)methanimine

Published Jul 7, 2021 · Diana Becerra, J. Cobo, Juan C Castillo

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Abstract

We report the ambient-temperature synthesis of novel (E)-N-(3-(tert-butyl)-1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-yl)methanamine 3 in 81% yield by a condensation reaction between 3-(tert-butyl)-1-methyl-1H-pyrazol-5-amine 1 and 2-pyridinecarboxaldehyde 2 in methanol using magnesium sulfate as a drying agent. The N-pyrazolyl imine 3 was full characterized by IR, 1D, and 2D NMR spectroscopy, mass spectrometry, and elemental analysis.

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This study demonstrates an efficient, ambient-temperature synthesis of novel (E)-N-(3-(tert-butyl)-1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-yl)methanamine 3 in 81% yield, with potential applications in

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Ambient-Temperature Synthesis of (E)-N-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-yl)methanimine

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References

Functional Pyrazolo[1,5-a]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold

Current advances in synthesis and functionalization of pyrazolo[1,5-a]pyrimidines show potential for anticancer drugs and enzyme inhibitors.

3-(tert-Butyl)-N-(4-methoxybenzyl)-1-methyl-1H-pyrazol-5-amine

This one-pot two-step synthesis of 3-(tert-butyl)-N-(4-methoxybenzyl)-1-methyl-1H-pyrazol-5-amine 3 offers operational ease, short reaction time, and no need for isolation and purification of the intermediate.

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Recent advances in pyrazole scaffold synthesis and functionalization show promise for developing therapeutics for neurodegenerative diseases like Alzheimer's and Parkinson's.

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Recent advances in the synthesis of pyrazole derivatives using various methodologies have shown promising biological activities, including anti-pyretic, anti-microbial, anti-inflammatory, antitumor, and anti-viral properties.

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Recent studies link pyrazole derivatives to anticancer activities in various cell lines, potentially benefiting various cancer types.

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