The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity.

doi:10.1016/j.bmcl.2013.10.032

Paper

The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity.

Published Dec 15, 2013 · J. Weon, Hyun-Jeong Ko, C. Ma

Bioorganic & medicinal chemistry letters

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Abstract

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Non-RCT

Animal Study

Study Snapshot

2,3-dihydroxy-4-methoxyacetophenone improves cognitive function and may help treat Alzheimer's disease by enhancing memory and protecting against neurotoxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity.

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References

Neuroprotective compounds isolated from Cynanchum paniculatum

Cynanchum paniculatum roots contain neuroprotective compounds, with compound 4 showing the most effective protection against glutamate-induced neurotoxicity in hippocampal HT22 cells.

Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress

Meloxicam and Selegiline, when co-administered, significantly improve memory and cognitive impairments in mice by inhibiting lipid peroxidation, enhancing antioxidant enzymes, and decreasing acetylcholinesterase activity.

The cholinergic system in aging and neuronal degeneration

Aging-associated cholinergic deficits and cognitive impairments may be prevented by early anti--amyloid strategies.

The cholinergic system and spatial learning

Acetlylcholine plays a crucial role in spatial memory formation in humans and rodents, with no clear distinction between muscarinic and nicotinergic systems.

Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus - a medicinal mushroom.

Chaga, a medicinal mushroom, significantly improves learning and memory in mice by reducing oxidative stress and inhibiting acetylcholinesterase activity.

Citations

Cynanchum paniculatum (Bunge) Kitag. ex H. Hara: A review of its ethnopharmacology, phytochemistry and pharmacology.

Cynanchum paniculatum (Bunge) is a traditional East Asian medicinal plant with numerous chemical ingredients and various pharmacological activities, including anti-inflammatory, antitumor, neuroprotection, and treating snake bites.

Paniculatumoside G, a new C_21 steroidal glycoside from Cynanchum paniculatum

Paniculatumoside G, a new C 21 steroidal glycoside, was isolated from the roots and rhizomes of Cynanchum paniculatum, a commonly used Traditional Chinese Medicine.

Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H₂O₂-induced cytotoxicity in PC12 cells.

Aloe-emodin improves cognitive deficits in mice and prevents oxidative stress-induced cytotoxicity in PC12 cells, suggesting potential neuroprotective effects against Alzheimer's disease.

Neurocognitive Improvement Through Plant Food Bioactives: A Particular Approach to Alzheimer’s Disease

Plant food bioactives show potential in improving neurocognitive function and reducing Alzheimer's disease risk, with potential benefits for both Alzheimer's disease and other neurodegenerative disorders.

aniculatumoside G , a new C 21 steroidal glycoside from Cynanchum

Paniculatumoside G, a new C21 steroidal glycoside, was identified and characterized from the roots and rhizomes of Cynanchum paniculatum, a commonly used Traditional Chinese Medicine.