Paper
Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid as anti-inflammatory agents free of ulcerogenic liability.
Published Dec 15, 2007 · Meenakshi Sharma, S. M. Ray
Bioorganic & medicinal chemistry letters
Q2 SJR score
7
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid show good anti-inflammatory and analgesic activity without ulcerogenic liability, but fail to decrease secondary lesions of adjuvant induced arthritis and inhibit TNF
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Involvement of Phenobarbital and SKF 525A in the Hepatotoxicity of Antifungal Drugs Itraconazole and Fluconazole in Rats
Inhibiting CYP may play a key role in the mechanism of hepatotoxicity induced by itraconazole and fluconazole, with phenobarbital providing hepatoprotection and SKF 525A enhancing hepatotoxicity.
2006·23citations·N. Somchit et al.·Drug and Chemical Toxicology
Drug and Chemical Toxicology
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors.
The most potent 2-phenoxy-indan-1-one derivative shows high acetylcholinesterase inhibitory activity (IC50 = 50 nM), with molecular docking studies suggesting it is well-adjusted to AChE.
2005·57citations·R. Sheng et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
Hybrid nitric oxide-releasing NSAIDs with a diazen-1-ium-1,2-diolate moiety show potential for prophylactic prevention of thrombus formation and adverse cardiovascular events.
2005·110citations·Carlos A. Velázquez et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity.
(E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent centrally acting muscle relaxant with antiinflammatory and analgesic properties, has been discovered and is in phase I clinical trials.
2003·53citations·D. Musso et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.
Novel compounds with dual AChE and MAO inhibitory activities show potential for treating Alzheimer's disease, with potential for further development.
2002·226citations·J. Sterling et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Citations
Synthesis, thermal, rheological characteristics, and enzymatic degradation of aliphatic polyesters with lignin‐based aromatic pendant groups
Lignocellulosic biodegradable polyesters with lignin-based aromatic groups show improved thermal quality and higher thermal decomposition temperatures compared to commercial alternatives.
2019·10citations·C. Arza et al.·Journal of Polymer Science Part A: Polymer Chemistry
Journal of Polymer Science Part A: Polymer Chemistry
INDANYL ANALOGS AS POTENTIAL ANTIMICROBIAL AGENTS
Indanyl analogs show potential antibacterial and antifungal activities, with compounds 4a, 5a, 5b, 5d, 5e, 5i, and 5j showing superior antifungal activities compared to standard drugs ciprofloxacin and fluconazole.
2018·3citations·S. Mandal·Asian Journal of Pharmaceutical and Clinical Research
Asian Journal of Pharmaceutical and Clinical Research
Synthesis and anti-inflammatory activity evaluation of a novel series of 6-phenoxy-[1,2,4]triazolo[3,4-a]phthalazine-3-carboxamide derivatives.
Compounds 6h and 6i show potent anti-inflammatory activity, with compound 6i showing the lowest cellular toxicity, and are similar to the reference drug dihydrotanshinone.
2016·35citations·Dachuan Liu et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Investigation of condensation products of aldehydes with acetoacetic ester catalyzed by organic bases: absolute configuration determination by X-ray crystallography and tautomeric equilibria studies by NMR spectroscopy
-keto esters 3a-e exist as a mixture of keto and enol isomers in chloroform solutions, with keto tautomers dominating the equilibriums.
2015·2citations·Chao-yue Chen et al.·Research on Chemical Intermediates
Research on Chemical Intermediates
New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: synthesis and antinociceptive evaluation.
Compound 13 shows the best peripheral analgesic activity, with its activity linked to a peripheral mechanism, after oral administration.
2013·10citations·M. Since et al.·European journal of medicinal chemistry
European journal of medicinal chemistry