The amination of 3-bromo-2-ethoxy-1,5-naphthyridine. A reinvestigation

doi:10.1002/RECL.19800990303

Paper

The amination of 3-bromo-2-ethoxy-1,5-naphthyridine. A reinvestigation

Published Sep 2, 2010 · H. V. D. Haak, H. Plas

Recueil des Travaux Chimiques des Pays-Bas

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Abstract

The reaction of 3-bromo-2-ethoxy-1,5-naphthyridine with KNH2/NH3 was reinvestigated. The procedure, described in the literature for the preparation of the title compound does not lead to this compound but to the isomeric 3-bromo-1-ethyl-1,5-naphthyridin-2(1H)-one. Reaction of this compound with KNH2/NH3 yields 3- and 4-amino-1-ethyl-1,5-naphthyridin-2(1H)-one, the latter being the main product. The title compound was prepared on reacting 2,3-dibromo-1,5-naphthyridine with sodium ethoxide. A mixture of 3- and 4-amino-2-ethoxy-1,5-naphthyridine was obtained on amination of 3-bromo-2-ethoxy-1,5-naphthyridine. In both cases the intermediacy of the respective 3,4-didehydro compounds was proposed.

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The amination of 3-bromo-2-ethoxy-1,5-naphthyridine with KNH2/NH3 yields 3- and 4-amino-1-ethyl-1,5-naphthyridin-2(1H)-one, not the iso

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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The amination of 3-bromo-2-ethoxy-1,5-naphthyridine. A reinvestigation

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