Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A.

doi:10.1021/ol9016639

Paper

Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A.

Published Aug 7, 2009 · Vasudha Sharma, Gilbert T Kelly, Jennifer Foulke-Abel

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Abstract

Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B produced.

Study Snapshot

Aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A, with its production influenced by the availability of biosynthetic precursors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A.

References

Citations

Biosynthesis of DNA-Alkylating Antitumor Natural Products

DNA-alkylating antitumor natural products show significant antitumor activity, but their biosynthesis and self-resistance mechanisms require further research for rational design of DNA alkylating agents.

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Squaramide-substituted calix[4]pyrrole 2 shows enhanced binding affinities for anions in CH2 Cl2, due to the squaramide unit's participation in anion binding.

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Azinomycin biosynthesis involves incorporation of 18O-labeled molecular oxygen and two other heavy atoms, providing insights into the formation of the azabicyclo[3.1.0]hexane ring and functionalization of this ring system.

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Aziridine-1,2,3-triazole hybrid derivatives show promising anticancer activity against human leukemia HL-60 and hepatoma G2 cells.