Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.

doi:10.1016/j.bmc.2012.12.004

Paper

Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.

Published Mar 15, 2013 · A. Alafeefy, S. Işık, H. Abdel‐Aziz

Bioorganic & medicinal chemistry

Q2 SJR score

51

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Abstract

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Study Snapshot

New benzenesulfonamides with cyanoacrylamide moieties show low nanomolar or subnanomolar inhibitory effects on tumor-associated carbonic anhydrase IX and XII, offering potential as antitumor agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.

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