Paper

Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.

Published Jun 1, 2009 · O. Güzel, A. Maresca, A. Scozzafava

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

These positively-charged sulfonamides show excellent inhibitory activity against tumor-associated carbonic anhydrase IX and XII, making them potential diagnostic tools or therapeutic agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.

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