Antiarrhythmic effect of desethylamiodarone in conscious rats

doi:10.1111/j.2042-7158.1987.tb03426.x

Paper

Antiarrhythmic effect of desethylamiodarone in conscious rats

Published Jun 1, 1987 · A. Varró, I. Bódi, G. Rabloczky

Journal of Pharmacy and Pharmacology

Q2 SJR score

4

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

The effect of desethylamiodarone, a metabolite of amiodarone, was studied in the early phase of arrhythmias induced by coronary artery ligation in conscious rats. Desethylamiodarone pretreatment improved survival without altering the occurrence of different types of arrhythmias during the first 20 min after coronary ligation. It was concluded that desethylamiodarone may contribute to the antiarrhythmic effect seen after chronic amiodarone treatment.

Non-RCT

Animal Study

Study Snapshot

Desethylamiodarone pretreatment improves survival in conscious rats with coronary artery ligation, potentially contributing to the antiarrhythmic effect seen after chronic amiodarone treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Antiarrhythmic effect of desethylamiodarone in conscious rats

Sign up to use Study Snapshot

References

Antiarrhythmic effect of acute and chronic amiodarone treatment in conscious rats

Chronic amiodarone pretreatment is more effective than acute one in reducing ventricular fibrillation in conscious rats after coronary artery ligation.

Pharmacodynamic studies of amiodarone and its active N-desethyl metabolite.

Desethylamiodarone has significantly greater electrophysiologic effects than amiodarone, potentially causing significant electrophysiologic changes in chronically treated patients.

Effects of Amiodarone and its Metabolite, Desethylamiodarone, on the Electrophysiologic Properties of Isolated Cardiac Muscle

Amiodarone and its metabolite desethylamiodarone (DAM) both have similar electrophysiologic effects in isolated cardiac muscle, with varying effects depending on the drug concentration.

Alterations to the electrical activity of atrial muscle isolated from the rat heart, produced by exposure in vitro to amiodarone

Amiodarone slows down the heart's electrical activity, prolonging action potential duration and decreasing V-max, with effects lasting up to hours at low concentrations.

Ventricular fibrillation in a conscious canine preparation of sudden coronary death--prevention by short- and long-term amiodarone administration.

Both short-term intravenous and long-term oral amiodarone effectively prevent ventricular fibrillation in conscious dogs with acute myocardial ischemia, but long-term oral amiodarone may have greater efficacy due to additional electrophysiologic action.

Citations

Long-term pretreatment with desethylamiodarone (DEA) or amiodarone (AMIO) protects against coronary artery occlusion induced ventricular arrhythmias in conscious rats.

Long-term pretreatment with DEA or amiodarone effectively protects against acute coronary artery occlusion-induced ventricular arrhythmias in conscious rats, offering an equivalent antiarrhythmic effect.

Amiodarone. An overview of its pharmacological properties, and review of its therapeutic use in cardiac arrhythmias.

Amiodarone is an effective, broad-spectrum antiarrhythmic drug with potential benefits in preventing sudden death in some patients.