Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review

doi:10.3390/nu10010036

Paper

Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review

Published Jan 1, 2018 · Yalda Shokoohinia, Fataneh Jafari, Z. Mohammadi

Nutrients

Q1 SJR score

74

Citations

2

Influential Citations

Open Access PDF Full text Semantic Scholar

Abstract

Cancer is caused by uncontrolled cell proliferation which has the potential to occur in different tissues and spread into surrounding and distant tissues. Despite the current advances in the field of anticancer agents, rapidly developing resistance against different chemotherapeutic drugs and significantly higher off-target effects cause millions of deaths every year. Osthol is a natural coumarin isolated from Apiaceaous plants which has demonstrated several pharmacological effects, such as antineoplastic, anti-inflammatory and antioxidant properties. We have attempted to summarize up-to-date information related to pharmacological effects and molecular mechanisms of osthol as a lead compound in managing malignancies. Electronic databases, including PubMed, Cochrane library, ScienceDirect and Scopus were searched for in vitro, in vivo and clinical studies on anticancer effects of osthol. Osthol exerts remarkable anticancer properties by suppressing cancer cell growth and induction of apoptosis. Osthol’s protective and therapeutic effects have been observed in different cancers, including ovarian, cervical, colon and prostate cancers as well as chronic myeloid leukemia, lung adenocarcinoma, glioma, hepatocellular, glioblastoma, renal and invasive mammary carcinoma. A large body of evidence demonstrates that osthol regulates apoptosis, proliferation and invasion in different types of malignant cells which are mediated by multiple signal transduction cascades. In this review, we set spotlights on various pathways which are targeted by osthol in different cancers to inhibit cancer development and progression.

Systematic Review

Very Rigorous Journal

Highly Cited

Study Snapshot

Osthol shows remarkable anticancer properties by suppressing cancer cell growth and inducing apoptosis in various cancers, with potential therapeutic applications in various malignancies.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review

References

Safety Assessment of Osthole Isolated from Prangos ferulacea : Acute and Subchronic Toxicities and Modulation of Cytochrome P450

Osthole is a moderately toxic substance when administered intravenously, with subchronic exposure impairing kidney function and inducing CYP1A2, CYP2E1, and CYP2C11.

Anticancer effects of novel resveratrol analogues on human ovarian cancer cells.

Novel resveratrol analogues show enhanced anti-cancer properties in ovarian cancer models, inhibiting cell growth and reducing migration.

Osthole inhibits bone metastasis of breast cancer

Osthole, a major extract from Cnidium monnieri, shows potential as a therapeutic agent for treating breast cancer bone metastases by inhibiting cell growth, migration, and invasion.

Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective

Nanoformulations of natural polyphenols, such as resveratrol and curcumin, improve bioavailability, targeted therapy, and stability, enhancing their anticancer potential.

Osthole enhances TRAIL-mediated apoptosis through downregulation of c-FLIP expression in renal carcinoma Caki cells.

Osthole, a constituent from Cnidium monnieri fruit, effectively sensitizes cancer cells to TRAIL-induced apoptosis through downregulation of c-FLIP expression.

Citations