Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT₁A/5-HT₂A/5-HT₇ and dopamine D₂/D₃ receptors.

doi:10.1016/j.ejmech.2012.11.042

Paper

DOI: 10.1016/j.ejmech.2012.11.042

Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT₁A/5-HT₂A/5-HT₇ and dopamine D₂/D₃ receptors.

Published Feb 1, 2013 · P. Zajdel, Krzysztof Marciniec, A. Máslankiewicz

European journal of medicinal chemistry

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

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Study Snapshot

New quinoline- and isoquinoline-sulfonamide analogs of aripiprazole show significant antidepressant and antipsychotic properties, targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/j.bmc.2011.12.039

Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation.

LCAP derivatives show potential as multi-receptor antidepressants and anxiolytics, with lead compound 36 showing significant antipsychotic properties in mice.

2012·61citations·P. Zajdel et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

DOI: 10.1016/j.bmc.2011.09.044

Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands.

Compound 54 is a potent 5-HT7 antagonist with good selectivity over 5-HT1A, 5-HT2A, and 5-HT6 receptors, reducing immobility in mice similar to SB-269970.

2011·34citations·P. Zajdel et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

DOI: 10.2165/11593740-000000000-00000

Maintenance Treatment Study Designs in Bipolar Disorder

Future maintenance research in bipolar disorder should use a prophylaxis design, not a relapse prevention design, to better prove atypical neuroleptics as mood stabilizers.

2011·34citations·F. Goodwin et al.·CNS Drugs

CNS Drugs

DOI: 10.1021/jm101459g

Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.

Compound 5m (Lu AA21004) is a novel multimodal serotonergic compound with potential for treating major depressive disorder by affecting multiple serotonin receptors and the serotonin transporter.

2011·395citations·B. Bang-Andersen et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1007/s00213-010-2097-z

The role of serotonin receptor subtypes in treating depression: a review of animal studies

Different serotonin receptor subtypes play a complex role in the antidepressant-like effects of SSRIs, offering potential for developing newer, more effective antidepressants.

2011·229citations·Gregory V. Carr et al.·Psychopharmacology

Psychopharmacology

Citations

DOI: 10.1371/journal.pone.0315394

Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians

Planarian behavioral medium-throughput screening (MTS) complements in silico cheminformatics and is an inexpensive, 3R alternative for identifying new neuroactive drug candidates.

2025·0citations·D. Ireland et al.·PLOS ONE

PLOS ONE

DOI: 10.1016/j.bioorg.2024.108076

Current development in sulfonamide derivatives to enable CNS-drug discovery.

Sulfonamide-based derivatives show potential in treating central nervous system diseases, offering diverse opportunities for developing novel agents for treating CNS disorders.

2024·0citations·Klaudia Blicharz-Futera et al.·Bioorganic chemistry

Bioorganic chemistry

DOI: 10.1039/d4ob01071j

Cu(II)-catalyzed synthesis of N-sulfonated quinolin-2(1H)-one-3-carboxamides.

Cu(II)-catalyzed N-sulfonated quinolin-2-(1H)-one-3-carboxamides were successfully synthesized in 52%-97% yields, leading to a 3,4-dihydro-quinolin-2(1H)-one

2024·0citations·Xue Chen et al.·Organic & biomolecular chemistry

Organic & biomolecular chemistry

DOI: 10.22159/ijap.2024v16i6.52023

NOVEL HYBRIDS OF QUINOLINE LINKED PYRIMIDINE DERIVATIVES AS CYCLOOXYGENASE INHIBITORS: MOLECULAR DOCKING, ADMET STUDY, AND MD SIMULATION

Quinoline-linked pyrimidine derivatives show strong binding affinities to COX enzymes, stable interactions in MD simulations, and favorable drug-like features, suggesting potential as anti-inflammatory drugs.

2024·0citations·D. K et al.·International Journal of Applied Pharmaceutics

International Journal of Applied Pharmaceutics

DOI: 10.1039/d4cs00369a

Recent synthetic strategies for the functionalization of fused bicyclic heteroaromatics using organo-Li, -Mg and -Zn reagents.

Organo-Li, -Mg, and -Zn reagents are effective for selective functionalization of fused bicyclic heteroaromatics, offering valuable synthetic routes for bioactive drugs and natural products.

2024·1citation·Vasudevan Dhayalan et al.·Chemical Society reviews

Chemical Society reviews

DOI: 10.1016/j.molstruc.2024.140072

Design, synthesis and molecular docking study of novel quinoline–triazole molecular hybrids as anticancer agents

Novel quinoline-triazole molecular hybrids show potential as anticancer agents, with compounds 6h, 8i, 8l, and 8n showing superior activity compared to standard drug Doxorubicin.

2024·2citations·Rajubai D. Bakale et al.·Journal of Molecular Structure

Journal of Molecular Structure

DOI: 10.1080/00397911.2024.2397813

Synthesis, anti-microbial evaluation, and in silico studies of novel quinoline-isoxazole hybrids

Novel quinoline-isoxazole hybrids 6a-o show promising antimicrobial activity against various bacteria and fungi, with compounds 6i, 6j, and 6l showing excellent binding properties with E. coli DNA gyrase.

2024·1citation·Deep P. Mandir et al.·Synthetic Communications

Synthetic Communications

DOI: 10.1007/s41061-024-00459-8

Reaction Pattern and Mechanistic Aspects of Iodine and Iodine-Based Reagents in Selenylation of Aliphatic, Aromatic, and (Hetero)Cyclic Systems.

Iodine and iodine-based reagents efficiently selenylate a broad range of organic substrates, allowing for regioselective and stereoselective approaches in organoselenium compound synthesis.

2024·0citations·Pankaj Kumar et al.·Topics in current chemistry

Topics in current chemistry