Anti-hyperglycemic effect of 11-hydroxypalmatine, a palmatine derivative from Stephania glabra tubers

doi:10.1080/10286020903117325

Paper

Anti-hyperglycemic effect of 11-hydroxypalmatine, a palmatine derivative from Stephania glabra tubers

Published Feb 1, 2010 · D. Semwal, U. Rawat, R. Semwal

Journal of Asian Natural Products Research

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32

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Abstract

A palmatine derivative, named 11-hydroxypalmatine (4), has been isolated from the tubers of Stephania glabra, together with three known alkaloids, palmatine (1), dehydrocorydalmine (2), and stepharanine (3). The structures of the compounds were elucidated by means of spectroscopic analysis including 2D NMR experiments. The hypoglycemic activity of 4 was evaluated against alloxan-induced diabetic mice. The test compound was administered at doses of 25, 50, and 100 mg/kg, p.o., 36 h after alloxan injection (60 mg/kg, i.v.). The alloxan-induced diabetic mice showed significant reduction in blood glucose after treatment with the test compound by 52% as compared to the positive control glibenclamide (54%) and the diabetic control (27%).

Non-RCT

Animal Study

Study Snapshot

11-hydroxypalmatine, a palmatine derivative from Stephania glabra tubers, significantly reduces blood glucose levels in alloxan-induced diabetic mice by 52% compared to glibenclamide and diabetic control.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Anti-hyperglycemic effect of 11-hydroxypalmatine, a palmatine derivative from Stephania glabra tubers

References

Gindarudine, a novel morphine alkaloid from Stephania glabra

Gindarudine 1, a novel morphine alkaloid, has been isolated from Stephania glabra tubers, along with four known alkaloids.

Antimicrobial hasubanalactam alkaloid from Stephania glabra.

Glabradine, a novel hasubanalactam alkaloid from Stephania glabra, exhibits potent antimicrobial activity against various bacteria, outperforming novobiocin and erythromycin.

Anti-diabetic and hypolipidemic effects of aqueous-extract from the flower of Inula japonica in alloxan-induced diabetic mice.

Inula japonica flower extract has both anti-diabetic and hypolipidemic effects, reducing blood glucose levels and triglyceride levels in diabetic mice more effectively than gliclazide and metformin.

Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants

This handbook provides a comprehensive catalog of more than 15,000 phytochemical constituents from over 1,000 plant species, useful for pharmacologists, toxicologists, nutritionists, and food scientists.

Alloxan-induced diabetes in the rat - protective action of (-) epicatechin?

(-)epicatechin and (+)catechin do not prevent or reverse alloxan-induced diabetes in rats, and do not relieve symptoms like poor weight gain, polyuria, or polydipsia.

Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor

This study developed a two-solution technique for determining glucose in blood using glucose oxidase and 4-amino phenazone, resulting in a stable color development in 10 minutes and a high stability reagent for manual and automated methods.

The alkaloids ofStephania glabra

Alkaloids from Stephania glabra tubers have been isolated from India, the Caucasus, and the Black Sea littoral, with further study on alkaloid A.

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