Paper
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
Published Nov 19, 2005 · Kenjiro Matsumoto, S. Horie, H. Takayama
Life sciences
Q1 SJR score
111
Citations
9
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Non-RCT
Animal Study
Highly CitedStudy Snapshot
7-hydroxymitragynine, an opioid alkaloid from the Thai herb Mitragyna speciosa, exhibits a potent analgesic effect through activation of mu-opioid receptors, with cross-tolerance to morphine and naloxone-induced
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa.
7-hydroxymitragynine, a novel opioid agonist from the Thai medicinal herb Mitragyna speciosa, has potent analgesic activity when orally administered, more potent than morphine.
2004·219citations·Kenjiro Matsumoto et al.·Life sciences
Life sciences
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
Mitragynine pseudoindoxyl and 7-hydroxymitragynine are structurally different opioid agonists with higher potency than morphine, exhibiting analgesic activity in mice and guinea pig ileum.
2002·222citations·H. Takayama et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Book Review: The Pharmacology of Mu Analgesics: From Patients to Genes
Mu opioids show complex pharmacological profiles, with differences in sensitivity to antisense probes and gene knockout models, highlighting the complexity of mu opioid pharmacology.
2001·115citations·G. Pasternak·The Neuroscientist
The Neuroscientist
A novel kappa-opioid receptor agonist, TRK-820, blocks the development of physical dependence on morphine in mice.
TRK-820 effectively blocks the development of physical dependence on morphine in mice, suggesting its potential role in modulating morphine addiction.
2000·31citations·M. Tsuji et al.·Life sciences
Life sciences
Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action.
DPHD, an alkaloid from Siphocampylus verticillatus, effectively reduces pain in mice through multiple mechanisms, including opioid systems, L-arginine-nitric oxide pathways, and glucocorticoids.
1999·91citations·A. Santos et al.·The Journal of pharmacology and experimental therapeutics
The Journal of pharmacology and experimental therapeutics
Citations
A review on multi-therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine: experimental evidence and future perspectives
Mitragynine and 7-hydroxymitragynine from Mitragyna speciosa (kratom) show potential as pharmacologically active compounds, but more research is needed on other parts of the plant and less costly extraction methods.
2025·0citations·Taslima Begum et al.·Kuwait Journal of Science
Kuwait Journal of Science
An in vitro evaluation on metabolism of mitragynine to 9-O-demethylmitragynine.
Kratom's major alkaloid, mitragynine, is metabolized to 9-O-demethylmitragynine, which shows potential for opioid cessation and pain management, but potential drug interactions remain unclear.
2024·0citations·Philip W. Melchert et al.·Chemico-biological interactions
Chemico-biological interactions
Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety.
Multiple neuronal models and key neurodevelopmental process assays are necessary for effective neurotoxicity screening of botanicals.
2024·1citation·Jyotshna Kanungo et al.·Expert opinion on drug metabolism & toxicology
Expert opinion on drug metabolism & toxicology
Kratom: a primer for pain physicians.
Kratom use as an opioid-sparing alternative in pain management is not without significant risks, and pain physicians should be aware of potential complications, including seizures and death.
2024·0citations·Trent D. Emerick et al.·Current opinion in anaesthesiology
Current opinion in anaesthesiology
A Platform for the Synthesis of Corynantheine-Type Corynanthe Alkaloids.
This study presents a catalytic, asymmetric platform for rapid access to corynantheine-type alkaloids, enabling comprehensive biological investigation of kratom alkaloids.
2023·2citations·Yunchan Nam et al.·Journal of the American Chemical Society
Journal of the American Chemical Society
An in vitro evaluation of kratom (Mitragyna speciosa) on the catalytic activity of carboxylesterase 1 (CES1).
Kratom extracts and its major alkaloids show reversible inhibition of CES1, making a drug-drug interaction unlikely across doses of 2-20g per dose.
2023·2citations·Philip W. Melchert et al.·Chemico-biological interactions
Chemico-biological interactions
Kratom Alkaloids, Cannabinoids, and Chronic Pain: Basis of Potential Utility and Role in Therapy.
Kratom and cannabis products are used for self-treatment of chronic pain, with potential additive or synergistic therapeutic benefits, but more research is needed to confirm their effectiveness.
2023·3citations·Daniel J Farkas et al.·Cannabis and cannabinoid research
Cannabis and cannabinoid research
The Health Impact of Long-Term Kratom (Mitragyna Speciosa) Use in Southern Thailand
Long-term kratom use in Southern Thailand does not increase common health complaints but may pose a drug dependence risk, with severe users experiencing intense withdrawal symptoms.
2023·1citation·Darika Saingam et al.·Substance Use & Misuse
Substance Use & Misuse