Summary Bioassays with chicks have shown that 2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridine is a very potent inhibitor of pyridoxine. Under the conditions of these experiments, two molecules of the inhibitor were sufficient to offset the vitamin activity of one molecule of pyridoxine. This ratio was found to hold for suboptimal and optimal amounts of pyridoxine given to pyridoxine-deficient chicks.

2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridine is a potent inhibitor of pyridoxine in chicks, with two molecules being sufficient to offset the vitamin activity of one pyridoxine molecule.

Paper

Antipyridoxine Activity of 2, 4-Dimethyl-3-Hydroxy-5-Hydroxymethylpyridine in the Chick

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