Antitumor activity of 4-nitropyridazine 1-oxides and related compounds for AH-13.

doi:10.1248/cpb.25.504

Paper

Antitumor activity of 4-nitropyridazine 1-oxides and related compounds for AH-13.

Published 1977 · S. Kamiya, M. Anzai, T. Nakashima

Chemical & pharmaceutical bulletin

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7

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0

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Abstract

Antitumor activity of 4-nitropyridazine 1-oxides and related compounds was tested with AH-13 system. Among these nitro compounds, 3, 6-dimethoxy-4-nitropyridazine 1-oxide (III) and 4-nitrocinnoline 1-oxide (XIII) were the most effective. 4-Nitropyridazine 1-oxide (I), 3, 6-dimethyl-4-nitropyridazine 1-oxide (II) and 3-alkoxy-4-nitro-6-chloropyridazine 1-oxides (VI, VII) were effective to some extent.

In Vitro Study

Study Snapshot

4-nitropyridazine 1-oxides show promising antitumor activity, with 3-dimethoxy-4-nitropyridazine 1-oxide (III) and 4-nitrocinnoline 1-oxide (XIII) being the most effective compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Antitumor activity of 4-nitropyridazine 1-oxides and related compounds for AH-13.

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References

Citations

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New method for the synthesis of 3(2H)‐pyridazinones and their alkene precursors: Solvent‐free reactions under microwave irradiation

Microwave irradiation allows for the quick and solvent-free synthesis of 3(2H)-pyridazinones and their alkene precursors.

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