Paper
Antitumor activity of glycyrol via induction of cell cycle arrest, apoptosis and defective autophagy.
Published Dec 1, 2014 · Mei-Ying Xu, Yeong Shik Kim
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Q1 SJR score
31
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Glycyrol has antitumor activity by inducing cell death, apoptosis, and defective autophagy, potentially serving as a potential candidate for cancer therapy.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
Metformin inhibits tumor growth in esophageal squamous cell carcinoma by promoting autophagy and apoptosis, with Stat3-Bcl-2 pathway inactivation contributing to this effect.
2014·258citations·Y. Feng et al.·Cell Death & Disease
Cell Death & Disease
Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment.
Hinokitiol inhibits human colon cancer cell growth and suppresses tumor growth in mice by inducing S-phase arrest and apoptosis.
2013·60citations·Youn-Sun Lee et al.·Journal of natural products
Journal of natural products
Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells.
Withaferin A shows potential as a G2/M cell cycle regulator and therapeutic agent for prostate cancer by inducing mitotic catastrophe and growth arrest in prostate cancer cells.
2013·98citations·R. Roy et al.·Journal of natural products
Journal of natural products
Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer.
Isoliquiritigenin induces growth inhibition and apoptosis in human breast cancer by downregulating the arachidonic acid metabolic network and deactivating PI3K/Akt.
2013·78citations·Y. Li et al.·Toxicology and applied pharmacology
Toxicology and applied pharmacology
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response
Phospho-Ser/Thr-binding domains play crucial roles in regulating cell cycle progression and DNA damage response, allowing time for various types of DNA repair.
2013·255citations·H. Reinhardt et al.·Nature Reviews Molecular Cell Biology
Nature Reviews Molecular Cell Biology
Citations
Glycyrol targets Pneumolysin (PLY) oligomerization to reduce Streptococcus pneumoniae toxicity
Glycyrol, a major component of licorice, reduces the invasiveness of Streptococcus pneumoniae by interacting with Pneumolysin, without affecting the growth of S. pneumoniae or Pneumolysin production.
2024·0citations·Yudi Li et al.·Frontiers in Pharmacology
Frontiers in Pharmacology
Plant-derived glycosides in cancer treatment: diverse strategies for tumor suppression.
Plant-derived glycosides show potential as novel cancer treatments due to their diverse biological activities, including apoptosis induction, cell cycle arrest, inhibition of angiogenesis, suppression of metastasis, and immune modulation.
2024·0citations·Prithviraj T·Natural product research
Natural product research
Elucidation of the anti-gastric cancer mechanism of Guiqi Baizhu Formula by integrative approach of chemical bioinformatics.
Guiqi Baizhu Formula, with key components glycyrol and emodin, inhibits gastric cancer cell proliferation and migration, promoting apoptosis.
2024·0citations·Yanru Wang et al.·International immunopharmacology
International immunopharmacology
A synergistic mechanism of Liquiritin and Licochalcone B from Glycyrrhiza uralensis against COPD.
The combination of LCB and LQ from Glycyrrhiza uralensis extract significantly reduces COPD symptoms by downregulating HCK, a key enzyme involved in oxidative stress, inflammation, and fibrosis.
2024·2citations·Shi Dong et al.·Phytomedicine : international journal of phytotherapy and phytopharmacology
Phytomedicine : international journal of phytotherapy and phytopharmacology
Three New Compounds, Licopyranol A–C, Together with Eighteen Known Compounds Isolated from Glycyrrhiza glabra L. and Their Antitumor Activities
Licopyranol A-1 and glycyrol-5, both found in Glycyrrhiza glabra L., show promising anti-colorectal cancer activities by inhibiting cell proliferation and promoting apoptosis in colorectal cancer RKO cells.
2022·0citations·Shanshan Wang et al.·Metabolites
Metabolites