Therapeutic Antiviral Action of 5-Trifluoromethyl-2'-deoxyuridine in Herpes Simplex Keratitis

doi:10.1126/science.145.3632.585

Paper

DOI: 10.1126/science.145.3632.585

Therapeutic Antiviral Action of 5-Trifluoromethyl-2'-deoxyuridine in Herpes Simplex Keratitis

Published Aug 7, 1964 · H. Kaufman, C. Heidelberger

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159

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Abstract

5-Trifluoromethyl-2'-deoxyuridine (F3TDR) has potent therapeutic antiviral activity in herpes simplex infection of the rabbit cornea with strains of herpes virus both sensitive and resistant to 5-iodo-2'-deoxyuridine, and in corneal infection with vaccinia. 5-Trifluoromethyl uracil is not therapeutically active in herpetic keratitis.

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Study Snapshot

5-Trifluoromethyl-2'-deoxyuridine effectively treats herpes simplex keratitis in rabbit corneas, with potential for use in herpetic keratitis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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