Antiviral activities of 5-chlorobenzotriazole derivatives

doi:10.1007/s00706-018-2234-7

Paper

Antiviral activities of 5-chlorobenzotriazole derivatives

Published Jun 9, 2018 · DOI · R. Ibba, P. Corona, A. Carta

Monatshefte für Chemie - Chemical Monthly

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Abstract

In this study, we designed and synthesized a series of new 5-chlorobenzotriazole derivatives. Compounds were tested for cytotoxicity and antiviral activity in cell-based assays against several positive single-stranded RNA viruses: BVDV, YFV, CVB-5, and Sb-1; two negative single-stranded RNA viruses: RSV and VSV; a double-stranded RNA virus (Reo-1); and two DNA viruses: VV and HSV-1. N-[4-(5-Chloro-2H-benzo[d][1,2,3]triazol-2-yl)phenyl]-3,4,5-trimethoxybenzamide turned out to be the most potent compound against bovine viral diarrhea virus (BVDV). Its activity was shown to be comparable to the activity of the reference drug NM 107 (EC50 3.0 vs. 1.7 μM). It is going to be used as a lead compound for future antiviral drug developments.Graphical abstract

In Vitro Study

Study Snapshot

N-[4-(5-Chloro-2H-benzo[d][1,2,3]triazol-2-yl)phenyl]-3,4,5-trimethoxybenzamide] shows potent antiviral activity against bovine viral diarrhea virus (BVDV), comparable to reference drug NM

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Antiviral activities of 5-chlorobenzotriazole derivatives

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