Application of PEG400 in the one-pot synthesis of 7-[4-alkyl- or (hetero)aryl-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridines via SNAr and Cu(I)-Catalyzed Azide-Alkyne Cycloaddition and preliminary evaluation of their anti-tumour activity

doi:10.1016/j.tetlet.2020.151900

Paper

Application of PEG400 in the one-pot synthesis of 7-[4-alkyl- or (hetero)aryl-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridines via SNAr and Cu(I)-Catalyzed Azide-Alkyne Cycloaddition and preliminary evaluation of their anti-tumour activity

Published May 28, 2020 · Juliana M. Rodrigues, R. Calhelha, I. Ferreira

Tetrahedron Letters

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5

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Abstract

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In Vitro Study

Study Snapshot

PEG 400 enables the one-pot synthesis of novel anti-tumor compounds, with a 2-ethynylpyridine derivative showing promising anti-tumor activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Application of PEG400 in the one-pot synthesis of 7-[4-alkyl- or (hetero)aryl-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridines via SNAr and Cu(I)-Catalyzed Azide-Alkyne Cycloaddition and preliminary evaluation of their anti-tumour activity

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References

Citations

Recent advancements in the synthesis of fused thienopyridines and their therapeutic applications

Recent advancements in fused thienopyridine synthesis and their therapeutic applications have led to diverse applications in various diseases and drug discovery.

Sustainable click reactions: Use of greener reaction media in the synthesis of 1,2,3-triazoles

Recent advances in "click" chemistry using greener reaction media, such as water, ethanol, glycerol, PEG, and solvent-free processes, have shown promising results in synthesizing 1,2,3-triazoles.

Magnetoliposomes Containing Multicore Nanoparticles and a New Antitumor Thienopyridine Compound with Potential Application in Chemo/Thermotherapy

Magnetoliposomes containing multicore nanoparticles and a new antitumor thienopyridine compound show potential for combined cancer therapy, offering potential for combined magnetic hyperthermia and chemotherapy.