Paper
Application of Pyridinium 1,4-Zwitterionic Thiolates: Synthesis of Benzopyridothiazepines and Benzothiophenes.
Published Apr 24, 2020 · Bin Cheng, Yun Li, Taimin Wang
The Journal of organic chemistry
Q2 SJR score
30
Citations
1
Influential Citations
Abstract
Pyridinium 1,4-zwitterionic thiolates, as a novel kind of sulfur-containing synthons, have been applied to the synthesis of 12aH-benzo[f]pyrido[1,2-d][1,4]thiazepines and benzo[b]thiophenes. Ben-zopyridothiazepines were produced through a 1,5-dipolar cycloaddition reaction from pyridinium 1,4-zwitterionic thiolates with arynes, whereas benzothiophenes as side products were generated via a [3+2] cascade cyclization. The [5+2] reaction mode of pyridinium 1,4-zwitterionic thiolates is disclosed for the first time.
Study Snapshot
Pyridinium 1,4-zwitterionic thiolates can be used to synthesize benzopyridothiazepines and benzothiophenes, with the [5+2] reaction mode being disclosed for the first time.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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