Applications of 2-arylhydrazononitriles in synthesis: preparation of new indole containing 1,2,3-triazole, pyrazole and pyrazolo[1,5-a]pyrimidine derivatives and evaluation of their antimicrobial activities.

doi:10.1016/j.ejmech.2011.02.040

Paper

Applications of 2-arylhydrazononitriles in synthesis: preparation of new indole containing 1,2,3-triazole, pyrazole and pyrazolo[1,5-a]pyrimidine derivatives and evaluation of their antimicrobial activities.

Published May 1, 2011 · H. Behbehani, H. M. Ibrahim, S. Makhseed

European journal of medicinal chemistry

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In Vitro Study

Study Snapshot

2-arylhydrazononitriles can be used to synthesize new, uniquely substituted heterocyclic substances with promising antimicrobial activities against Gram negative, Gram positive, and Yeast.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Applications of 2-arylhydrazononitriles in synthesis: preparation of new indole containing 1,2,3-triazole, pyrazole and pyrazolo[1,5-a]pyrimidine derivatives and evaluation of their antimicrobial activities.

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References

Citations

Insights into Novel Arylazopyrazolo[1,5-a]pyrimidines as Promising MurA Inhibitors and Antibiofilm Candidates: Design, Synthesis, Antimicrobial Evaluation, and Molecular Docking

Novel pyrazolo[1,5-a]pyrimidine derivatives show promising antibacterial properties and potential as MurA inhibitors, with compound 4c showing potential as an antibiofilm agent and reducing hemolysis.

Synthesis and biological evaluation of [1,2,3]triazolo[4',5':3,4]pyrrolo[1,2-a] indoles: one-pot reaction under microwave irradiation

Compounds 4h, 4j, and 4k show greater antibacterial activity and higher antioxidant activity compared to conventional Trolox, while compounds 4d, 4i, and l show comparable activity.

Chemistry of 3-cyanoacetyl indoles: synthesis, reactions and applications: a recent update

3-cyanoacetyl indoles (CAIs) are versatile starting materials for the synthesis of various heterocyclic compounds with potential biological and pharmaceutical activities.

Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi‐active components combination

Combining Chinese herbal medicines with other drugs can improve antitumor activity, selectivity, and reduce side effects, potentially accelerating new drug research and development.

Formal Nitrene Insertion into the β-Vinyl C-H Bond of Acroleins: Synthesis of Enaminals.

The developed formal nitrene insertion reaction efficiently produces secondary enaminals in high yield with a broad substrate scope, making it a promising method for synthesis of -amino alcohols.

Investigation of biological activities of various 1,2,3‐triazole compounds: Their effects on cholinesterase enzymes, determination of antioxidant capacity and antimicrobial activity

Compound 4 shows the best antimicrobial activity and antioxidant activity, while compound 3 shows stronger butyrylcholinesterase inhibition compared to other compounds.

Indole Fused Benzimidazole Hybrids: A Promising Combination to Fulfill Pharmacological Significance

Indole-benzimidazole hybrid derivatives show potential in improving pharmacological properties and structure-activity relationships, aiding in drug discovery and design.

Domino Aza-Michael-SNAr-Heteroaromatization Route to C5-Substituted 1-Alkyl-1H-Indole-3-Carboxylic Esters

This study presents a new synthesis of C5-substituted 1-alkyl-1H-indole-3-carboxylic esters using an aza-Michael-SNAr-heteroaromatization route, resulting in 61-92% of ind