Paper
Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.
Published Feb 1, 2017 · M. James, S. Jahn, Guo Zhong
Pharmacology & therapeutics
Q1 SJR score
110
Citations
4
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Highly CitedStudy Snapshot
Dichloroacetate (DCA) has therapeutic applications in treating inherited mitochondrial disorders, pulmonary hypertension, and various solid tumors, but its effect on its own metabolism complicates the selection of effective doses with minimal side effects.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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Pharmacogenetic considerations with dichloroacetate dosing.
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Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation.
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Citations
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