A radiochemical assay method for carboxylesterase, and comparison of enzyme activity towards the substrates methyl [1-14C] butyrate and 4-nitrophenyl butyrate.

doi:10.1016/0006-2952(85)90579-9

Paper

DOI: 10.1016/0006-2952(85)90579-9

A radiochemical assay method for carboxylesterase, and comparison of enzyme activity towards the substrates methyl [1-14C] butyrate and 4-nitrophenyl butyrate.

Published Aug 1, 1985 · S. Sterri, B. A. Johnsen, F. Fonnum

Biochemical pharmacology

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Abstract

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In Vitro Study

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Study Snapshot

Carboxylesterase preferentially hydrolyzes methyl butyrate and 4-nitrophenyl butyrate, with the latter group being crucial for soman detoxification.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Polyfluoroalkyl-containing 4-AHPs show potential as pharmaceuticals due to their anticarboxylesterase, antioxidant, anti-cancer, and anti-inflammatory properties, with potential for cell visualization and analgesic effects.

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Methylene blue-cycloalkaneindole conjugates show potential as multitarget neuroprotective drugs by simultaneously acting on multiple targets, providing cognitive stimulating, neuroprotective, and disease-modifying effects.

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Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity

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SYNTHESIS AND BIOLOGICAL EVALUATION OF POLYFLUOROALKYL-CONTAINING 4-ARYLHYDRAZINYLIDENE-ISOXAZOLES AS ANTIFUNGAL AGENTS WITH ANTIOXIDANT ACTIVITY

Polyfluoroalkyl-containing 4-arylhydrazinylidene-isoxazoles show antifungal activity and high antioxidant activity, potentially benefiting hepatotoxicity reduction.

2021·3citations·N. A. Elkina et al.·Journal of Fluorine Chemistry

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Specificity of Saliva Esterases by Wine Carboxylic Esters and Inhibition by Wine Phenolic Compounds Under Simulated Oral Conditions

Saliva esterases are specific to wine odorant carboxylic esters and inhibited by wine phenolic compounds, with catechin being the most inhibitory compound.

2021·7citations·M. Pérez-Jiménez et al.·Frontiers in Nutrition

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Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands

New aminoadamantane and -carboline conjugates show potential as neuroprotectants and cognition enhancers with a multifunctional mode of action against Alzheimer's disease and other neurodegenerative disorders.

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