The use of bacitracin as an inhibitor of the degradation of thyrotropin releasing factor and luteinizing hormone releasing factor.

doi:10.1016/0006-291X(76)90736-1

Paper

The use of bacitracin as an inhibitor of the degradation of thyrotropin releasing factor and luteinizing hormone releasing factor.

Published Nov 22, 1976 · J. McKelvy, P. Leblanc, C. Laudes

Biochemical and biophysical research communications

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130

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4

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

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Study Snapshot

Bacitracin effectively inhibits the degradation of thyrotropin releasing factor 1 and luteinizing hormone releasing factor in vitro, without degrading itself during in vitro incubation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The use of bacitracin as an inhibitor of the degradation of thyrotropin releasing factor and luteinizing hormone releasing factor.

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References

Metabolism of thyrotropin releasing factor in two clonal cell lines of nervous system origin.

TRF metabolism in clonal cell lines from nervous system tumors is similar to that in guinea pig brain or hypothalamus, making them ideal model systems for studying TRF metabolism.

Regulation of degradation of thyrotropin releasing hormone by thyroid hormones

Thyroid hormones control the activity of the enzyme(s) that degrades thyrotropin releasing hormone, regulating its activity and determining hormone secretion by the anterior pituitary.

Distribution of LH-RH in subcellular fractions of the basomedial hypothalamus

The majority of LH-RH in the basomedial hypothalamus is found within nerve endings, consistent with previous cyto-immunological data on neuropeptide distribution in the rat hypothalamus.

Biosynthesis of thyrotropin-releasing hormone in organ cultures of the guinea pig median eminence.

Guinea pig median eminence organ cultures show high preservation of ependymal cell morphology and sustained ability to accumulate [3H]L-proline, but neuronal integrity declines over time.

Studies of enzymatic degradation of luteinizing hormone‐releasing hormone by different tissues

LH-RH undergoes rapid inactivation in various tissues, and inhibitors may be needed to prevent its degradation.

Enzymic degradation of luteinizing hormone-releasing hormone (LH-RH) by hypothalamic tissue.

Hypothalamic tissue rapidly degrades synthetic LH-RH, causing its inactivation and loss of hormonal activity within 5 minutes.

BIOSYNTHESIS OF THYROTROPIN RELEASING FACTOR BY NEWT (TRITURUS VIRIDESCENS) BRAIN IN VITRO. ISOLATION AND CHARACTERIZATION OF THYROTROPIN RELEASING FACTOR

Newt TRF is identical to mammalian TRF and its storage and synthesis are not confined to the hypothalamus in this species.

Independence of glucagon receptors and glucagon inactivation in liver cell membranes.

Glucagon receptors and glucagon inactivation in liver cell membranes may be functionally or structurally related, affecting our understanding of hormone-receptor interactions and receptor isolation.

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